1,1,1,3,3,3هگزافلوئورو 2 پروپانول برای سنتز DNA و پپتید
| Chemical formula | CFCH(OH)CF |
| Molar Mass | 168.04 g/mol |
| CAS Number | 920-66-1 |
| HS Code | 2905 59 90 |
| Storage | Store below +30°C |
| SDS | available |
| RTECS | UB6450000 |
| Boiling point | 58 °C (1013 hPa) |
| Density | 1.616 g/cm3 (20 °C) |
| pH value | 3 – 4 (HO) Aqueous solution |
| Vapor pressure | 205 hPa (25 °C) |
| Description | Conforms | ||
| Identification | Conforms | ||
| Color | ≤ | 20 | Hazen |
| Water | ≤ | 0.02 | % |
| Density | 1.614 to 1.618 | ||
| Purity | ≥ | 99.0 | % |
1,1,1,3,3,3-Hexafluoro-2-propanol for DNA & Peptide synthesis is a high-purity, anhydrous fluorinated alcohol widely used as a solvent and reagent in peptide and oligonucleotide synthesis, as well as in preparative and analytical procedures in pharmaceutical and biochemical laboratories.
🏭⚗️ Production
The solvent is produced by high-purity synthesis and distillation under strictly controlled, moisture-free conditions to achieve anhydrous status and remove impurities. It is then packaged in sealed, moisture-resistant containers to preserve its chemical integrity and ensure consistent performance in regulated laboratory and industrial environments.
🔬 Properties
1,1,1,3,3,3-Hexafluoro-2-propanol is a clear, colorless to slightly viscous liquid with a relatively high polarity and moderate boiling point. It is fully miscible with many organic solvents and has limited solubility in water. The solvent is chemically stable under normal conditions but can react with strong bases and reducing agents. Its strong hydrogen-bonding capacity and unique fluorinated structure make it particularly suitable for solubilizing peptides, proteins, and nucleic acid derivatives.
🧪 Applications
In pharmaceutical and analytical laboratories, 1,1,1,3,3,3-hexafluoro-2-propanol is used for dissolving or solubilizing peptides and oligonucleotides during synthesis and purification workflows. It is applied as a solvent for preparative chromatography, lyophilization steps, and reaction media where enhanced solubility of fluorophilic or hydrophobic compounds is required. It is also used to improve peptide folding, stabilization, and to facilitate selective chemical modifications in laboratory-scale reactions.
⚠️ Safety
This solvent is flammable, irritant, and can be harmful if inhaled or absorbed through the skin. It should be handled in a well-ventilated fume hood with gloves, protective eyewear, and lab coats. Containers must be stored tightly sealed in a cool, dry place, away from heat, strong oxidizers, and incompatible materials. Waste and empty containers should be disposed of according to laboratory hazardous waste regulations.
