محلول سالین فیزیولوژیک فرموله‌شده

Formalized Physiological Saline Solution is a commonly used fixative solution in histology, combining physiological saline with formaldehyde to preserve tissue samples by preventing enzymatic degradation and maintaining cellular structure.

🏭⚗️ Production
This solution is typically prepared by mixing 90 mL of physiological saline (0.9% NaCl) with 10 mL of 10% formalin (formaldehyde solution). The formaldehyde acts as a fixative agent that crosslinks proteins and stabilizes tissues, preventing autolysis and decomposition.

🔬 Properties
The solution is colorless or slightly yellow with a pH close to 7.4, matching physiological conditions. It is isotonic with body fluids, maintaining osmotic balance. The formaldehyde component enables protein fixation by forming covalent bonds, preserving cellular morphology.

🧪 Applications
Widely used in histology and pathology labs for fixing tissue samples before microscopic examination. It preserves tissue architecture for staining protocols such as Hematoxylin and Eosin (H&E). Also used for long-term storage of biological specimens.

⚠️ Safety
Formaldehyde is toxic and a known carcinogen. Handle with caution in well-ventilated areas, using gloves and eye protection. Avoid inhalation and skin contact. Dispose of waste according to hazardous chemical regulations.