تری فلورو استیک اسید برای سنتزDNA و پپتید
| Formula | C2HF3O2 |
| Chemical formula | C2HF3O2 |
| Molar mass | 114.02 g/mol |
| Density | 1.48 g/m3 (20 °C) |
| CAS number | 76-05-1 |
| HS Code | 29159080 |
| EC number | 200-929-3 |
| Storage | Store at +15 to +30°C |
| SDS | available |
| R phrase | R 20-35-52/53 |
| S phrase | S 9-26-27-28.1-45-61 |
| Odour | pungent |
| Form | liquid |
| Color | colourless |
| Solubility in water | (20°C) freely soluble |
| Solubility in ethanol | soluble |
| Solubility in chloroform | freely soluble |
| Boiling point | 72°C |
| Melting point | _15°C |
| Vapour pressure | 141 hPa (20°C) |
| Viscosity dynamical | 0.91mPa*s (20°C) |
| Description | Conforms | ||
| Identification | Conforms | ||
| Solubility | Conforms | ||
| Spesific gravity | 1.487 to 1.490 | ||
| Absorbance @260 nm | ≤ | 1.0 | AU |
| Absorbance @300 nm | ≤ | 0.03 | AU |
| Purity | ≥ | 99.5 | % |
Trifluoroacetic acid for DNA & Peptide synthesis is a high-purity, strong organic acid widely used as a deprotection reagent and solvent additive in peptide and oligonucleotide synthesis, as well as in preparative and analytical procedures in pharmaceutical and biochemical laboratories.
🏭⚗️ Production
The acid is produced by high-purity synthesis and distillation under strictly controlled conditions to remove water and impurities. It is then packaged in sealed, corrosion-resistant containers to preserve its chemical integrity and ensure consistent performance in regulated laboratory and industrial environments.
🔬 Properties
Trifluoroacetic acid is a clear, colorless liquid with a sharp, acrid odor. It is fully miscible with water and most organic solvents, highly acidic, and chemically stable under normal storage conditions. Its strong acidity and volatility make it ideal for cleaving protecting groups in peptide synthesis and modifying solvent properties in chromatography and analytical workflows.
🧪 Applications
In pharmaceutical and analytical laboratories, trifluoroacetic acid is used for cleaving protecting groups during peptide synthesis. It also acts as a counter-ion in peptide and oligonucleotide purification via HPLC. Additionally, it modifies solvent systems to improve solubility, peak shape, and separation in preparative and analytical chromatography. It is further applied to facilitate selective chemical reactions and peptide modifications in laboratory-scale procedures.
⚠️ Safety
Trifluoroacetic acid is highly corrosive, toxic, and can cause severe burns upon contact with skin or eyes. It is volatile and its vapors can be harmful if inhaled. Therefore, it should be handled in a well-ventilated fume hood with gloves, protective eyewear, and lab coats. Containers must be stored tightly sealed in a cool, dry place, away from incompatible materials such as strong bases and reducing agents. Waste and empty containers should be disposed of according to laboratory hazardous waste regulations.
