🏭⚗️ Synthesis
Produced by esterifying sorbitan with oleic acid under heat and controlled conditions. Final product is primarily sorbitan monooleate, a viscous amber liquid with low HLB (~4.3).
🧪 Applications
Span 80 is a non-ionic surfactant used widely in:
Pharmaceuticals – for niosome and drug delivery systems
Cosmetics – in creams, lotions, and emulsions
Food industry – as emulsifier (E494)
Agriculture – in pesticide formulations
Industrial use – as a lubricant and antifoaming agent
⚠️ Safety
Low toxicity, but may cause mild skin/eye irritation
Avoid inhaling mist or prolonged contact
Biodegradable, but handle with care
Use PPE when handling; store in cool, dry conditions