Tetrahydrofuran (THF) for HPLC
| Formula | C4H8O |
| Chemical formula | C4H8O |
| Density | 0.89 g/Cm3 (20°C) |
| Molar mass | 72.11 g/mol |
| CAS number | 109-99-9 |
| HS Code | 29321100 |
| EC number | 203-726-8 |
| Storage | at +15 to +25 °C |
| SDS | available |
| RTECS | LU5950000 |
| R phrase | R 11-19-36/37 |
| S phrase | S 16-29-33 |
| Odour | ether – like |
| Form | liquid |
| Color | colourless |
| Explosion limit | 1.5 – 12.4 Vol % |
| Ignition temprature | 215 °C |
| p H value | 7 – 8 (200 g/l 20°C) |
| Solubility in water | soluble (20°C) |
| Flash point | -21.5°C |
| Boiling point | 65-66°C |
| Melting point | -108.5°C |
| Vapour pressure | 173 hPa |
| Viscosity dynamical | 0.48 mPa*s |
| Saturation concentration | 557 g/m3 |
| Assay | ≥ | 99.8 | % |
| Description | Conforms | ||
| Identification | Conforms | ||
| Solubility | Conforms | ||
| Density (d 20 °C/4 °C) | 0.887 – 0.889 | ||
| Peroxide (as H2O2) | ≤ | 0.010 | % |
| Free acid (as CH3COOH) | ≤ | 0.002 | % |
| Water | ≤ | 0.1 | % |
| Stabilized with BHT |
Tetrahydrofuran (THF) for HPLC is a high‑purity, analytical‑grade solvent used in pharmaceutical and analytical laboratories for HPLC, extraction, and sample preparation.
🏭⚗️ Production
Distilled and purified under strictly controlled conditions to remove water, peroxides, and trace impurities. Standardized for chemical purity, low water content, and stability. Supplied in chemically resistant, tightly sealed containers to prevent contamination, moisture uptake, or degradation.
🔬 Properties
A colorless, volatile liquid with a mild ether-like odor. Highly flammable, low density, and miscible with water and most organic solvents. Chemically reactive with strong oxidizers and can form explosive peroxides upon prolonged storage or exposure to air. Store in a cool, dry, well-ventilated area, protected from light, heat, sparks, and incompatible substances.
🧪 Applications
Used in pharmaceutical and analytical laboratories for HPLC mobile phase preparation, extraction of polar and non-polar compounds, and other analytical procedures requiring high-purity ether solvents. Maintains reproducibility and purity in chromatographic and extraction processes. Solutions and equipment should be handled to preserve analytical-grade quality.
⚠️ Safety
Highly flammable and potentially explosive upon peroxide formation. May cause irritation to eyes, skin, and respiratory tract; prolonged exposure may affect the central nervous system. Use in a well-ventilated area with appropriate protective equipment including gloves, goggles, and lab coat. Avoid ingestion and contact with incompatible substances. Store in a tightly closed, chemically resistant container in a cool, dry, well-ventilated area away from oxidizers, heat, sparks, and ignition sources.
