Isopropyl myristate
| Formula | C17H34O2 |
| Chemical formula | C17H34O2 |
| Density | 0.85 g/cm3 (20°C) |
| Molar mass | 270.46 g/mol |
| CAS number | 110-27-0 |
| HS Code | 29159080 |
| EC number | 203-751-4 |
| Storage | Store at 15 to 25 °C |
| SDS | available |
| Odour | almost odourless |
| Form | liquid |
| Color | colourless |
| Ignitition temprature | ≥ 300 °C |
| Solubility in water | 0.05 g/l (20°C) |
| Solubility in ethanol | soluble |
| Flash point | ≥ 150 °C |
| Boiling point | 140 °C (3 hPa) |
| Melting point | 0 -1 °C |
| Vapour pressure | ≤ 1 hPa |
| Thermal decomposition | 208 °C |
| Viscosity dynamical | 5.58 mPa*s (20°C) |
| Assay | ≥ | 90 | % |
| Description | Conforms | ||
| Identification | Conforms | ||
| Solubility | Conforms | ||
| Specific gravity | 0.846 – 0.854 | ||
| Acid value | 1 | ||
| Iodine value | 1 | ||
| Sapoification value | 202 – 212 | ||
| Refractive index | 1.432 – 1.436 | ||
| Residue on ignition | ≤ | 0/1 | % |
Isopropyl Myristate (IPM) is a synthetic ester of isopropyl alcohol and myristic acid, commonly used in pharmaceutical and laboratory applications as a solvent, penetration enhancer, and emollient. Its chemical structure and properties make it effective in facilitating the absorption of active ingredients through the skin and enhancing the solubility of various compounds.
🏭⚗️ Production
IPM is synthesized through the esterification of myristic acid with isopropyl alcohol in the presence of a catalyst, typically sulfuric acid. The reaction mixture is then purified to remove residual solvents and by-products, yielding a high-purity product suitable for pharmaceutical use. The synthesis process is carefully controlled to ensure consistency and quality in the final product.
🔬 Properties
IPM is a clear, colorless, and odorless liquid with a low viscosity, making it easy to incorporate into various formulations. It is miscible with alcohols and oils but immiscible with water. The compound exhibits low volatility and is stable under standard storage conditions. Its ability to enhance the permeability of the skin makes it valuable in topical drug delivery systems.
🧪 Applications
In pharmaceutical formulations, IPM is utilized as a solvent for oil-based drugs and as a vehicle for topical medications, including creams, gels, and ointments. It serves as a penetration enhancer, improving the delivery of active ingredients through the skin. Additionally, IPM is employed in laboratory settings as a solvent for various chemical reactions and as a component in formulations requiring enhanced skin absorption.
⚠️ Safety
IPM is generally recognized as safe for topical use when applied according to recommended guidelines. However, it may cause skin irritation in sensitive individuals. It should be stored in tightly sealed containers in a cool, dry place, away from light and incompatible substances. Proper handling and adherence to safety protocols are essential to ensure safe use in pharmaceutical and laboratory applications.
