Dipotassium hydrogen phosphate HPLC
| Formula | HK2O4P |
| Chemical formula | K2HPO4 |
| Density | 2.44 g/cm3 (20°C) |
| Molar mass | 174.18 g/mol |
| Bulk density | ~ 700 -1000 kg/m3 |
| CAS number | 04/11/7758 |
| HS Code | 28352400 |
| EC number | 231- 834-5 |
| Storage | Without limitation |
| SDS | available |
| Odour | oderless |
| Form | solid |
| Color | white |
| p H | 9.0 (10g/l 20 °C) |
| Solubility in water | 1600 g/l (20°C) |
| Solubility in ethanol | slightly soluble (20°C) |
| Melting point | decomposition |
| Vapour pressure | >180 °C |
| Assay | 99.0 – 100.5 | % | |
| Description | Conforms | ||
| Solubility | Conforms | ||
| pH | 8.7 – 9.3 | ||
| Solubility color | Conforms | ||
| Solubility turbidity | Conforms | ||
| Identification | ≤ | Conforms | |
| Insoluble substances | ≤ | 0/2 | % |
| HPLC gradient suitability test | 10 | ppm | |
| (220,254,280 nm) chromophoric | |||
| impurities on 4-hydroxyacetophenon |
Dipotassium Hydrogen Phosphate for HPLC is a pharmacopeial-grade reagent designed for pharmaceutical and laboratory applications requiring precise buffer preparation and highly reproducible chromatographic performance.
🏭⚗️ Production
Manufactured under GMP- and pharmacopeial-compliant conditions using high-purity dipotassium hydrogen phosphate (HPLC or analytical grade). Supplied as a crystalline solid or pre-dissolved solution suitable for preparation of phosphate buffer systems and mobile phases in pharmaceutical and analytical laboratories. Produced in controlled environments to prevent contamination by ions, particulates, or organics. Packaged in airtight, chemically resistant containers to maintain stability and prevent moisture uptake. Each batch is validated according to USP, EP, and HPLC standards to ensure purity, uniformity, and reliability for analytical use.
🔬 Properties
A high-purity, white crystalline solid with defined phosphate content, excellent solubility, and stable buffering capacity in neutral to mildly alkaline pH ranges. Forms clear, colorless solutions suitable for pharmaceutical analysis. Slight clumping due to humidity may occur but does not affect analytical-grade performance and can be easily corrected by gentle mixing or dissolution.
🧪 Applications
Used in preparation of mobile phases, phosphate buffer systems, and pH adjustment in pharmaceutical research and quality control laboratories. Essential for HPLC analysis, method validation, and formulation studies requiring stable, precise phosphate buffers for separation of ionizable and polar compounds. Provides reproducible performance in drug analysis and routine laboratory assays.
⚠️ Safety
May cause irritation to eyes, skin, or respiratory tract. Avoid ingestion and inhalation. Use appropriate personal protective equipment (gloves, goggles, lab coat). Store in tightly sealed containers in a cool, dry environment to prevent moisture absorption. Dispose of according to laboratory, pharmacopeial, and environmental safety guidelines.
