Cetyle PEG/PPG-1/10 Dimethicone
| CAS number | 142321-71-9 |
| HS Code | 34021300 |
| Storage | Storage at 5 to 30°C |
| SDS | available |
| Appearance | Conforms | ||
| Solubility | Conforms | ||
| Refractive index | 1.4250 to 1.4450 | ||
| Specific gravity | 0.915 to 0.945 | ||
| HLB | ~ | 4.5 | |
| Viscosity | 700.0 to 2300.0 | mPa.s |
Cetyl PEG/PPG-1/10 Dimethicone is a silicone-based non-ionic emulsifier derived from the ethoxylation and propoxylation of cetyl dimethicone. It appears as a clear to slightly hazy, colorless or pale yellow liquid with low odor and is widely used in pharmaceutical and laboratory formulations for its emulsifying, solubilizing, and skin-conditioning properties.
🏭⚗️ Production
Cetyl PEG/PPG-1/10 Dimethicone is produced by reacting cetyl dimethicone with controlled amounts of ethylene oxide (PEG) and propylene oxide (PPG) under regulated conditions. This process results in a mixture of PEG/PPG-modified dimethicone molecules that are liquid at room temperature, providing excellent compatibility with both aqueous and oily phases in pharmaceutical and laboratory formulations.
🔬 Properties
Cetyl PEG/PPG-1/10 Dimethicone is soluble in both water and organic solvents, chemically stable, and has low viscosity. It functions as an effective emulsifier and solubilizer, enhancing the dispersion of hydrophobic active ingredients. Its silicone backbone provides excellent skin-conditioning and protective effects without causing irritation.
🧪 Applications
In pharmaceutical formulations, Cetyl PEG/PPG-1/10 Dimethicone is used in topical creams, ointments, gels, and lotions to stabilize oil-in-water emulsions and improve the feel and spreadability of products. It also acts as a carrier for fat-soluble vitamins, herbal extracts, and other active pharmaceutical ingredients, facilitating their delivery and absorption.
In laboratory settings, this compound is used as an emulsifying and solubilizing agent in experimental formulations, microemulsions, and drug delivery studies, ensuring stability and uniform distribution of active compounds.
⚠️ Safety
Cetyl PEG/PPG-1/10 Dimethicone is generally considered safe for topical use at recommended concentrations. It is non-toxic, non-irritating, and hypoallergenic for most users. Standard handling procedures, including proper storage and hygiene, should be followed to ensure safety during pharmaceutical or laboratory use.
