Buffer solution pH 4.00
| Density: | 1.002 g/cm3 |
| HS code: | 38220000 |
| Storage | Without limilations. |
| SDS | not required |
| Form: | liquid |
| pH-Value 20°C | 4 | ± | 0.02% |
| 0 °C | ΔpH | 0.01 | |
| 5 °C | ΔpH | 0.01 | |
| 10 °C | ΔpH | 0.01 | |
| 15 °C | ΔpH | 0.01 | |
| 20 °C | ΔpH | ±0.00 | |
| 25 °C | ΔpH | ±0.00 | |
| 30 °C | ΔpH | -0.02 | |
| 35 °C | ΔpH | -0.02 | |
| 40 °C | ΔpH | -0.04 | |
| 50 °C | ΔpH | -0.05 |
Buffer Solution pH 4.00 is a pharmacopeial-grade reference solution designed for use in pharmaceutical quality control, laboratory calibration, and analytical testing for the calibration and performance verification of pH meters, electrodes, and other pH-sensitive analytical instruments requiring stable acidic reference standards.
🏭⚗️ Production
Prepared under strictly controlled GMP- and pharmacopeial-compliant conditions to ensure precise pH, chemical stability, and minimal contamination. The pH 4.00 value is achieved using high-purity acidic buffer components—commonly potassium hydrogen phthalate or citrate–phosphate blends—dissolved in deionized water to provide a stable and reproducible acidic reference. The solution is supplied in chemically resistant, sealed, and light-protected containers to prevent contamination, CO₂ absorption, or degradation. Each batch is validated according to USP <791>, EP 2.2.3, and relevant pharmaceutical testing standards to ensure accuracy, uniformity, and reproducibility.
🔬 Properties
A clear, colorless aqueous solution with a defined pH of 4.00 ± specified tolerance at 25 °C. Exhibits excellent stability under recommended storage conditions. Minor pH drift may occur after prolonged exposure to air, light, or elevated temperatures; gentle mixing restores homogeneity without affecting the reference value.
🧪 Applications
Used in pharmaceutical, analytical, and educational laboratories for calibration, validation, and performance testing of pH meters and electrodes, particularly for acidic-range measurements. Suitable for method validation, routine QC analysis, equipment qualification (IQ/OQ/PQ), and compliance with pharmacopeial standards requiring acidic pH reference solutions. Ideal for ensuring accurate measurements in formulation development, stability studies, process control, and laboratory research.
⚠️ Safety
Considered low-hazard but should be handled according to standard laboratory safety practices. Avoid ingestion, inhalation, and direct contact with skin and eyes. Use appropriate personal protective equipment, including gloves, goggles, and a lab coat. Store in tightly sealed, light-protected containers in a cool, dry environment. Dispose of according to pharmaceutical laboratory waste regulations and environmental safety guidelines.
