Acetyl tributyl citrate

Acetyl tributyl citrate is an organic compound that is used as a plasticizer. As such, it is a potential replacement of DEHP and DINP. It is a colorless liquid that is soluble in organic solvents. It is found in nail polish and other cosmetics. It is prepared by acetylation of tributyl citrate.
🏭⚗️ Synthesis
ATBC is synthesized through a two-step process. First, citric acid reacts with butanol to form tributyl citrate (TBC). Then, the TBC undergoes acetylation by reacting with acetic anhydride, which adds an acetyl group to the remaining hydroxyl group, producing Acetyl Tributyl Citrate.
🧪 Uses
ATBC is commonly used as a non-toxic plasticizer in a variety of industries.
It is used in the manufacture of PVC plastics, especially in sensitive products such as children’s toys, medical tubing, and blood bags, due to its safety and flexibility.
It is also used in food packaging materials, where it helps soften plastics without contaminating food.
In the cosmetic and personal care industry, ATBC acts as a solvent or softening agent in products like creams and lotions.
In pharmaceutical applications, it is used in tablet coatings to improve flexibility and control the release of active ingredients.
Additionally, ATBC is used in inks, coatings, and adhesives to enhance performance and plasticity.
⚠️ Safety
ATBC is considered to have low toxicity and is generally regarded as safe for human contact, even in food and medical use. It is biodegradable, meaning it breaks down naturally in the environment.
It causes minimal irritation to the skin and eyes and is not classified as a hazardous substance under most regulatory frameworks.
However, ingestion in large amounts may cause mild digestive discomfort. As with all chemicals, proper handling, including the use of gloves and ventilation during industrial use, is recommended.