Hexane-1-sulfonic acid sodium salt
| Formula | C6H13NaO3S |
| Chemical formula | C6H13NaO3S |
| molar mass | 188.22 g/mol |
| CAS number | 2832-45-3 |
| HS Code | 29041000 |
| EC number | 220-601-3 |
| Storage | Store at 15 to 30°C |
| SDS | available |
| Odour | odourless |
| Form | solid |
| Color | white |
| Solubility in water | freely soluble (20°C) |
| Assay | ≥ | 99.0 | % |
| Appearance | Conforms | ||
| Solubility | Conforms | ||
| Identification | Conforms | ||
| pH | 5.5 to 7.5 | ||
| UV- Transmission @ 200 nm | ≥ | 70.0 | % |
| UV- Transmission @ 220 nm | ≥ | 90.0 | % |
| UV- Transmission @ 250 nm | ≥ | 98.0 | % |
| Loss on drying | ≤ | 2.0 | % |
Hexane-1-sulfonic acid sodium salt (also known as sodium 1-hexanesulfonate) is a high-purity, analytical-grade ion-pairing reagent widely used in pharmaceutical and analytical laboratories, especially for reversed-phase HPLC separations of ionic and polar compounds.
🏭⚗️ Production
Manufactured through controlled sulfonation followed by neutralization and purification processes designed to minimize inorganic residues, moisture, and organic by-products. Subjected to fine filtration and stringent quality checks to ensure consistent particle size, high assay value, and low levels of UV-absorbing impurities. Packaged in airtight, chemically compatible containers to prevent hydration, contamination, or degradation during storage and handling.
🔬 Properties
A white to off-white crystalline solid, freely soluble in water and polar solvents. Exhibits strong ionic character and functions effectively as an ion-pairing agent due to the presence of a sulfonate group and a medium-chain alkyl moiety. Chemically stable under standard laboratory conditions but may absorb moisture if exposed to air. Store in a cool, dry location, protected from humidity and incompatible materials such as strong oxidizing agents.
🧪 Applications
Commonly used in reversed-phase HPLC as an ion-pairing reagent to enhance retention, resolution, and peak shape of charged analytes including amines, peptides, pharmaceuticals, and small ionic molecules. Supports method development for complex matrices and stability-indicating assays. Also employed in sample preparation and specialized chromatographic workflows where controlled ionic interactions are required for improved selectivity and reproducibility.
⚠️ Safety
May cause irritation to eyes, skin, and respiratory tract upon contact or inhalation of dust. Avoid generating dust and use in well-ventilated areas or fume hoods. Ingestion or significant exposure may be harmful. Handle using appropriate PPE such as gloves, safety goggles, and lab coat. Store in tightly sealed containers away from moisture, oxidizers, and incompatible chemicals, and follow standard laboratory hygiene practices when handling this reagent.
