Potassium dihydrogen phosphate for HPLC
| Formula | H2KO4P |
| Chemical formula | KH2PO4 |
| Density | 2.34 g/cm3 (20°C) |
| Molar mass | 136.09 g/mol |
| Bulk density | ~1200 kg/m3 |
| CAS number | 7778-77-0 |
| HS Code | 28352400 |
| EC number | 231- 913-4 |
| Storage | Without limitation |
| SDS | available |
| Odour | oderless |
| Form | solid |
| Color | white |
| p H | ~4.4 (10g/l 20 °C) |
| Solubility in water | 222 g/l (20°C) |
| Solubility in ethanol | insoluble (20°C) |
| Melting point | ~253 °C |
| Assay | 99.0 – 100.5 | % | |
| Description | Conforms | ||
| Solubility | Conforms | ||
| Solubility color | Conforms | ||
| Solubility turbidity | Conforms | ||
| pH | 4.1 – 4.5 | ||
| Identification | Conforms | ||
| Insoluble substances | ≤ | 0/2 | % |
| HPLC gradient suitability test | ≤ | 10 | ppm |
| (220,254,280 nm) chromophoric | |||
| impurities on 4-hydroxyacetophenon |
Potassium Dihydrogen Phosphate for HPLC is a pharmacopeial-grade reagent specifically formulated for pharmaceutical and laboratory applications requiring precise buffer preparation and reproducible chromatographic performance.
🏭⚗️ Production
Manufactured under GMP- and pharmacopeial-compliant conditions using high-purity potassium dihydrogen phosphate (HPLC or analytical grade). Supplied as a crystalline solid optimized for pharmaceutical buffer systems and mobile phase preparation. Produced in controlled laboratory environments to prevent ionic, particulate, or organic contamination. Packaged in chemically resistant, airtight containers to ensure stability and protect against moisture. Each batch is validated against USP, EP, and HPLC quality standards to guarantee uniformity, purity, and reliability for analytical and pharmaceutical use.
🔬 Properties
A high-purity, white crystalline solid with defined phosphate content, high solubility, and stable acidic to neutral buffering capacity. Solutions are clear, colorless, and highly stable, suitable for use in sensitive pharmaceutical assays. Slight clumping from humidity does not affect analytical performance and can be easily remedied by gentle mixing or dissolution.
🧪 Applications
Ideal for preparation of mobile phases, phosphate buffer systems, and pH adjustment in pharmaceutical analysis and research laboratories. Widely used in HPLC, QC testing, method validation, and formulation development where precise control of phosphate concentration and pH is critical for reproducible results in drug analysis.
⚠️ Safety
Can cause irritation to eyes, skin, and respiratory tract. Avoid ingestion and inhalation. Use proper PPE such as gloves, goggles, and lab coat. Store in a tightly sealed container in a cool, dry place to prevent moisture absorption. Dispose of following laboratory, pharmacopeial, and environmental safety guidelines.
